miR-34a sets the "sweet spot" for notch in colorectal cancer stem cells.

Cell stem cell ·Vol. 12 ·No. 5 ·2013-05-02 ·Pages 499-501

Winton DJ

Abstract

Mechanisms underlying alternative modes of symmetric versus asymmetric stem cell fates are not well understood. In this issue of Cell Stem Cell, Bu et al. (2013) find that miR-34a acts as a toggle switch for Notch signaling that dictates binary symmetric and asymmetric fates in colon cancer stem cells.

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Winton Douglas J

Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK. doug.winton@cruk.cam.ac.uk

Article Info

Journal

Cell stem cell

Abbr.

Cell Stem Cell

ISSN

1875-9777

DOI

10.1016/j.stem.2013.04.018

doug.winton@cruk.cam.ac.uk

Published

2013-05-02

Pages

499-501

Language

English

Region

United States

NLM ID

101311472

Corrections

CommentOn

PMID: 23642368

External Links

PubMed source DOI: 10.1016/j.stem.2013.04.018 View journal details

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miR-34a sets the "sweet spot" for notch in colorectal cancer stem cells.

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