miR-34a sets the "sweet spot" for notch in colorectal cancer stem cells.
作者:
Winton(Douglas J)
状态:
发布时间2013-05-06
, 更新时间 2016-05-18
期刊:
Cell Stem Cell
摘要:
Mechanisms underlying alternative modes of symmetric versus asymmetric stem cell fates are not well understood. In this issue of Cell Stem Cell, Bu et al. (2013) find that miR-34a acts as a toggle switch for Notch signaling that dictates binary symmetric and asymmetric fates in colon cancer stem cells.