Home LiteratureArticle Details
PMID: 23609796 Published · ppublish English Journal Article Comment

Set them free: F-box protein exchange by Cand1.

Cell research ·Vol. 23 ·No. 7 ·2013-07-00 ·Pages 870-1

Flick K, Kaiser P

Abstract

Cand1 (Cullin-associated and neddylation-dissociated protein 1) has long been known as a regulator of SCF ubiquitin ligases, but details remained puzzling due to conflicting results from in vitro and in vivo experiments. Three recent reports, one in Cell and two in Nature Communications, propose Cand1 as a protein exchange factor with interesting mechanism that reconciles Cand1 genetics and biochemistry.

MeSH Terms
Animals Humans SKP Cullin F-Box Protein Ligases/metabolism Saccharomyces cerevisiae/physiology Saccharomyces cerevisiae Proteins/physiology Schizosaccharomyces/metabolism Schizosaccharomyces pombe Proteins/metabolism Transcription Factors/metabolism
Chemicals
Saccharomyces cerevisiae Proteins Schizosaccharomyces pombe Proteins Transcription Factors SKP Cullin F-Box Protein Ligases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Flick Karin
Department of Biological Chemistry, School of Medicine, University of California Irvine, 240D Med Sci I, Irvine, CA 92697-1700, USA.
Kaiser Peter
References (11)
11 references, click to expand
  1. Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.
    Cell. 2013 Mar 28;153(1):206-15 PMID: 23453757
  2. The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.
    Cell. 2011 Nov 23;147(5):1024-39 PMID: 22118460
  3. Structural basis for a reciprocal regulation between SCF and CSN.
    Cell Rep. 2012 Sep 27;2(3):616-27 PMID: 22959436
  4. Structural regulation of cullin-RING ubiquitin ligase complexes.
    Curr Opin Struct Biol. 2011 Apr;21(2):257-64 PMID: 21288713
  5. The ubiquitin system, an immense realm.
    Annu Rev Biochem. 2012;81:167-76 PMID: 22663079
  6. CSN- and CAND1-dependent remodelling of the budding yeast SCF complex.
    Nat Commun. 2013;4:1641 PMID: 23535662
  7. Cullin-RING ubiquitin ligases: global regulation and activation cycles.
    Cell Div. 2008 Feb 18;3:7 PMID: 18282298
  8. CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire.
    Nat Commun. 2013;4:1642 PMID: 23535663
  9. NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.
    Mol Cell. 2002 Dec;10(6):1511-8 PMID: 12504025
  10. CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
    Mol Cell. 2002 Dec;10(6):1519-26 PMID: 12504026
  11. Function and regulation of cullin-RING ubiquitin ligases.
    Nat Rev Mol Cell Biol. 2005 Jan;6(1):9-20 PMID: 15688063
Article Info
Journal
Cell research
Abbr.
Cell Res
ISSN
1748-7838
DOI
10.1038/cr.2013.55
Published
2013-07-00
Epub
2013-00-23
Pages
870-1
Language
English
Region
England
NLM ID
9425763
PMCID
PMC3698631
Subset
IM
Corrections
CommentOn
PMID: 23453757
CommentOn
PMID: 23535662
CommentOn
PMID: 23535663
External Links
PubMed source DOI: 10.1038/cr.2013.55 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2