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题目:: Cancer risk in Lynch Syndrome.
作者:: Barrow(Emma),Hill(James),Evans(D Gareth)
状态:: 发布时间2013-07-22 , 更新时间 2013-07-22
期刊:: Fam Cancer
摘要:: Lynch Syndrome, or hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by inactivating mutations in DNA mismatch repair genes. It accounts for 2-4 % of all incident colorectal cancers. Mutation carriers are at risk of early onset colorectal cancer, endometrial cancer, and a spectrum of other tumours. Accurate estimation of cancer risk for mutation carriers is essential for counselling, and establishing appropriate screening guidelines. This study reviews the current data on cancer risk, and emerging risk reduction strategies.
语言:: eng
DOI:: 10.1007/s10689-013-9615-1

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