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PMID: 235736 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

On the involvement of a glucose 6-phosphate transport system in the function of microsomal glucose 6-phosphatase.

Molecular and cellular biochemistry ·Vol. 6 ·No. 2 ·1975-02-28 ·Pages 75-83

Arion WJ, Wallin BK, Lange AJ, Ballas LM

Abstract

A model for microsomal glucose 6-phosphatase (EC 3.1.3.9) is presented. Glucose 6-phosphatase is postulated to be resultant of the coupling of two components of the microsomal membrane: 1) a glucose 6-phosphate - specific transport system which functions to shuttle the sugar phosphate from the cytoplasm to the lumen of the endoplasmic reticulum; and 2) a catalytic component, glucose-6-P phosphohydrolase, bound to the luminal surface of the membrane. A large body of existing data was shown to be consistent with this hypothesis. In particular, the model reconciles well-documented differences in the kinetic properties of the enzyme of untreated and modified microsomal preparations. Characteristic responses of the enzyme to changes in nutritional and hormonal states may be attributed to adaptations which alter the relative capacities of the transport and catalytic components.

MeSH Terms
Animals Biological Transport, Active Cytoplasm/metabolism Deoxycholic Acid/pharmacology Edetic Acid/pharmacology Endoplasmic Reticulum/metabolism Glucose-6-Phosphatase/metabolism Glucosephosphates/metabolism Hydrogen-Ion Concentration Kidney/metabolism Kinetics Mathematics Membranes/drug effects,metabolism Microsomes/metabolism Microsomes, Liver/metabolism Models, Biological Ultrasonics
Chemicals
Glucosephosphates Deoxycholic Acid Edetic Acid Glucose-6-Phosphatase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Arion W J
Wallin B K
Lange A J
Ballas L M
References (30)
30 references, click to expand
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Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1007/BF01732001
Published
1975-02-28
Pages
75-83
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01732001 View journal details
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