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PMID: 2352949 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Characterization of ROS1 cDNA from a human glioblastoma cell line.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 87 ·No. 12 ·1990-06-00 ·Pages 4799-803

Birchmeier C, O'Neill K, Riggs M, Wigler M

Abstract

We have isolated and characterized a human ROS1 cDNA from the glioblastoma cell line SW-1088. The cDNA, 8.3 kilobases long, has the potential to encode a transmembrane tyrosine-specific protein kinase with a predicted molecular mass of 259 kDa. The putative extracellular domain of ROS1 is homologous to the extracellular domain of the sevenless gene product from Drosophila. No comparable similarities in the extracellular domains were found between ROS1 and other receptor-type tyrosine kinases. Together, ROS1 and sevenless gene products define a distinct subclass of transmembrane tyrosine kinases.

MeSH Terms
Amino Acid Sequence Base Sequence Cell Line DNA, Neoplasm/genetics,isolation & purification Gene Library Glioma Humans Molecular Sequence Data Oligonucleotide Probes Oncogene Proteins, Viral/genetics Oncogenes Protein Conformation Protein-Tyrosine Kinases/genetics RNA, Neoplasm/genetics,isolation & purification Receptor Protein-Tyrosine Kinases Sequence Homology, Nucleic Acid
Chemicals
DNA, Neoplasm Oligonucleotide Probes Oncogene Proteins, Viral RNA, Neoplasm Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases v-ros protein, Avian sarcoma virus UR2
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Birchmeier C
Max-Delbrueck-Laboratorium in der Max-Planck-Gesellschaft, Cologne, Federal Republic of Germany.
O'Neill K
Riggs M
Wigler M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.87.12.4799
Published
1990-06-00
Pages
4799-803
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC54205
Subset
IM
Databases
GENBANK
M34353
External Links
PubMed source DOI: 10.1073/pnas.87.12.4799 PMC Full Text View journal details
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