ROS links glucose metabolism to breast cancer stem cell and EMT phenotype.
作者:
Schieber(Michael S),Chandel(Navdeep S)
状态:
发布时间2013-03-22
, 更新时间 2016-10-25
期刊:
Cancer Cell
摘要:
Cancer stem cells display an epithelial-mesenchymal transition phenotype and are resistant to current therapies. In this issue of Cancer Cell, Dong and colleagues demonstrate that these phenotypes in basal-like breast cancer are promoted by a metabolic switch to glucose metabolism, resulting in decreased reactive oxygen species levels.