| GeneLibs

题目:: Central giant cell lesion of the jaws: study of CCND1 gene amplification and p16INK4a protein levels.
作者:: Nogueira(Renato Luiz Maia),Faria(Mário Henrique Girão),Osterne(Rafael Lima Verde),Cavalcante(Roberta Barroso),Ribeiro(Ronaldo Albuquerque),Nonaka(Cassiano Francisco Weege),Rabenhorst(Silvia Helena Barem)
状态:: 发布时间2013-10-01 , 更新时间 2013-10-01
期刊:: J Mol Histol
摘要:: Central giant cell lesions (CGCLs) are uncommon benign jaw lesions with uncertain etiology and a variable clinical behavior. In neoplasms, alterations in molecules involved in the G1/S checkpoint are frequently found. Loss of p16(INK4a) expression or overexpression of cyclin D1 may stimulate cell proliferation. The purpose of this study was to analyze CCND1 gene amplification and the expression of p16(INK4a) in CGCLs. Structural analysis of the CCND1 was performed using chromogenic in situ hybridization. Immmunohistochemistry was used to identify p16(INK4a) protein levels. Statistical analysis correlated the two biomarkers with clinical behavior and between each other. Twenty-four lesions were included, being 11 aggressive and 13 non-aggressive. Moderate/high-level CCND1 amplification was found in 12 lesions. Also, immunoreactivity for p16(INK4a) was present in 12 cases, mainly in mononuclear cells. There was a significantly higher level of p16(INK4a) expression in mononuclear cells of non-aggressive lesions and lesions with moderate/high-level CCND1 amplification in mononuclear cells. It could be speculated that some CGCLs may develop as a true benign neoplasm. The higher expression of p16(INK4a) in non-aggressive lesions and in cases with moderate/high-level CCND1 amplification may show that these molecules have a role in CGCLs.
语言:: eng
DOI:: 10.1007/s10735-013-9494-7

文献库文献相关信息

DataTable pData

联系方式

微信公众号

文献库 文献相关信息

DataTable pData

联系方式

微信公众号

文献库文献相关信息