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题目:: The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
作者:: Weinhold(Niels),Johnson(David C),Chubb(Daniel),Chen(Bowang),Försti(Asta),Hosking(Fay J),Broderick(Peter),Ma(Yussanne P),Dobbins(Sara E),Hose(Dirk),Walker(Brian A),Davies(Faith E),Kaiser(Martin F),Li(Ni L),Gregory(Walter A),Jackson(Graham H),Witzens-Harig(Mathias),Neben(Kai),Hoffmann(Per),Nöthen(Markus M),Mühleisen(Thomas W),Eisele(Lewin),Ross(Fiona M),Jauch(Anna),Goldschmidt(Hartmut),Houlston(Richard S),Morgan(Gareth J),Hemminki(Kari)
状态:: 发布时间2013-04-26 , 更新时间 2016-11-22
期刊:: Nat Genet
摘要:: A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 × 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.
语言:: eng
DOI:

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