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PMID: 2349953 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Mitochondrial DNA polymorphism reveals hidden heterogeneity within some Asian populations.

American journal of human genetics ·Vol. 47 ·No. 1 ·1990-07-00 ·Pages 87-94

Chakraborty R

Abstract

Use of data on mtDNA morph distributions from six Asian populations has shown that the observed number of different mtDNA morphs is too large when compared with the number expected on the basis of the observed gene diversity in the mtDNA genome. This excess number of morphs mainly occurs through an excess of rare morphs, and this discrepancy is more pronounced in a pooled sample of five Asian populations. It is suggested that this discrepancy is probably due to internal heterogeneity in each of the anthropologically defined populations. This analysis demonstrates the utility that population data for a single locus, such as the mtDNA genome, have for detecting hidden heterogeneity in populations, provided that the locus has substantial genetic variability, so that many variant alleles can be detected.

MeSH Terms
Asia DNA, Mitochondrial/genetics Ethnicity Humans Models, Statistical Polymorphism, Genetic
Chemicals
DNA, Mitochondrial
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Chakraborty R
Center for Demographic and Population Genetics, University of Texas Graduate School of Biomedical Sciences, Houston 77225.
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1990-07-00
Pages
87-94
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1683746
Subset
IM
Grants
NIGMS NIH HHS · GM 41399 · United States
External Links
PubMed source PMC Full Text View journal details
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