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题目:: Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas.
作者:: Van de Casteele(M),Leuckx(G),Baeyens(L),Cai(Y),Yuchi(Y),Coppens(V),De Groef(S),Eriksson(M),Svensson(C),Ahlgren(U),Ahnfelt-Rønne(J),Madsen(O D),Waisman(A),Dor(Y),Jensen(J N),Heimberg(H)
状态:: 发布时间2013-03-08 , 更新时间 2015-02-18
期刊:: Cell Death Dis
摘要:: We previously showed that injury by partial duct ligation (PDL) in adult mouse pancreas activates Neurogenin 3 (Ngn3)(+) progenitor cells that can differentiate to β cells ex vivo. Here we evaluate the role of Ngn3(+) cells in β cell expansion in situ. PDL not only induced doubling of the β cell volume but also increased the total number of islets. β cells proliferated without extended delay (the so-called 'refractory' period), their proliferation potential was highest in small islets, and 86% of the β cell expansion was attributable to proliferation of pre-existing β cells. At sufficiently high Ngn3 expression level, upto 14% of all β cells and 40% of small islet β cells derived from non-β cells. Moreover, β cell proliferation was blunted by a selective ablation of Ngn3(+) cells but not by conditional knockout of Ngn3 in pre-existing β cells supporting a key role for Ngn3(+) insulin(-) cells in β cell proliferation and expansion. We conclude that Ngn3(+) cell-dependent proliferation of pre-existing and newly-formed β cells as well as reprogramming of non-β cells contribute to in vivo β cell expansion in the injured pancreas of adult mice.
语言:: eng
DOI:

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