| GeneLibs

题目:: Cancer metabolism: fatty acid oxidation in the limelight.
作者:: Carracedo(Arkaitz),Cantley(Lewis C),Pandolfi(Pier Paolo)
状态:: 发布时间2013-03-22 , 更新时间 2016-10-25
期刊:: Nat Rev Cancer
摘要:: Warburg suggested that the alterations in metabolism that he observed in cancer cells were due to the malfunction of mitochondria. In the past decade, we have revisited this idea and reached a better understanding of the 'metabolic switch' in cancer cells, including the intimate and causal relationship between cancer genes and metabolic alterations, and their potential to be targeted for cancer treatment. However, the vast majority of the research into cancer metabolism has been limited to a handful of metabolic pathways, while other pathways have remained in the dark. This Progress article brings to light the important contribution of fatty acid oxidation to cancer cell function.
语言:: eng
DOI:

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