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题目:: Cyclin D1 polymorphism in non-small cell lung cancer in a Portuguese population.
作者:: Catarino(R),Coelho(A),Nogueira(A),Araújo(A),Gomes(M),Lopes(C),Medeiros(R)
状态:: 发布时间2013-02-11 , 更新时间 2013-02-11
期刊:: Cancer Biomark
摘要:: Cyclin D1 (CCND1) is a key regulatory protein of the cell cycle. The purpose of our study was to assess the role of CCND1 genetic variants influencing the genetic susceptibility of non-small cell lung cancer (NSCLC). We conducted a study of 1234 individuals, including 892 controls and 342 cases. Individuals carrying two G-alleles have a 2-fold increased risk for the development of NSCLC and the waiting time for onset of NSCLC in these patients was 2 years earlier in comparison with other individuals. Our results may be important in contributing to the knowledge of the mechanisms involved in lung carcinogenesis.
语言:: eng
DOI:: 10.3233/CBM-130294

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