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PMID: 233913 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Eosinophils and resistance to Trichinella spiralis.

The Journal of experimental medicine ·Vol. 145 ·No. 3 ·1977-03-01 ·Pages 755-9

Grove DI, Mahmoud AA, Warren KS

Abstract

Mice infected with Trichinella spiralis were depleted of eosinophils by repeated administration of rabbit anti-mouse eosinophil serum. There was no effect on the spontaneous expulsion of adult worms from the small intestines, but the numbers of larvae in the muscles were almost doubled. It is concluded that eosinophils contribute to resistance to the systemic phase of trichinosis.

MeSH Terms
Animals Antibody-Dependent Cell Cytotoxicity Eosinophils/immunology Inflammation/immunology Intestine, Small/parasitology Mice Muscles/parasitology Rabbits Trichinella spiralis/immunology Trichinellosis/immunology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Grove D I
Department of Medicine, Case Western Reserve University, University Hospitals, Cleveland, Ohio 44106.
Mahmoud A A
Warren K S
References (10)
10 references, click to expand
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    J Exp Med. 1975 Oct 1;142(4):805-13 PMID: 1185104
  7. Eosinophils as mediators of antibody-dependent damage to schistosomula.
    Nature. 1975 Aug 28;256(5520):727-9 PMID: 1153011
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    J Exp Med. 1975 Sep 1;142(3):560-74 PMID: 1165468
  9. Mechanism of eosinophilia. II. Role of the lymphocyte.
    J Exp Med. 1970 Jun 1;131(6):1288-305 PMID: 5419272
  10. Mechanism of eosinophilia. I. Factors affecting the eosinophil response of rats to Trichinella spiralis.
    J Exp Med. 1970 Jun 1;131(6):1271-87 PMID: 5419271
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.145.3.755
Published
1977-03-01
Pages
755-9
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2180703
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.145.3.755 PMC Full Text View journal details
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