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PMID: 2335223 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The antioxidant action of tamoxifen and its metabolites. Inhibition of lipid peroxidation.

FEBS letters ·Vol. 263 ·No. 2 ·1990-04-24 ·Pages 192-4

Wiseman H, Laughton MJ, Arnstein HR, Cannon M, Halliwell B

Abstract

The anti-oestrogen drug tamoxifen is an inhibitor of lipid peroxidation in rat liver microsomes and in phospholipid liposomes. Its cis isomer and N-desmethyl form are weaker inhibitors, but 4-hydroxytamoxifen is much more powerful. It is possible that the antioxidant property of tamoxifen might contribute to its biological actions.

MeSH Terms

Animals Antioxidants Ascorbic Acid/pharmacology Chlorides Ferric Compounds/pharmacology In Vitro Techniques Lipid Peroxidation/drug effects Male Microsomes, Liver/metabolism Rats Tamoxifen/analogs & derivatives,pharmacology

Chemicals

Antioxidants Chlorides Ferric Compounds Tamoxifen Ascorbic Acid ferric chloride

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Wiseman H

Department of Biochemistry, University of London, King's College, Strand Campus, UK.

Laughton M J

Arnstein H R

Cannon M

Halliwell B

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(90)81371-t

Published

1990-04-24

Pages

192-4

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(90)81371-t View journal details

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The antioxidant action of tamoxifen and its metabolites. Inhibition of lipid peroxidation.

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