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PMID: 23349877 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Toll-like receptor ligands induce expression of the costimulatory molecule CD155 on antigen-presenting cells.

PloS one ·Vol. 8 ·No. 1 ·2013-00-00 ·Pages e54406

Kamran N, Takai Y, Miyoshi J, Biswas SK, Wong JS, Gasser S

Abstract

Genotoxic stress and RAS induce the expression of CD155, a ligand for the immune receptors DNAM-1, CD96 and TIGIT. Here we show that antigen-presenting cells upregulate CD155 expression in response to Toll-like receptor activation. Induction of CD155 by Toll-like receptors depended on MYD88, TRIF and NF-κB. In addition, IRF3, but not IRF7, modulated CD155 upregulation in response to TLR3 signals. Immunization of CD155-deficient mice with OVA and the TLR9 agonist CpG resulted in increased OVA-specific IgG2a/c titers when compared to wild type mice. Splenocytes of immunized CD155-deficient mice secreted lower levels of IL-4 and fewer IL-4 and GATA-3 expressing CD4(+) T cells were present in the spleen of Cd155(-/-) mice. Our data suggest that CD155 regulates T(h)2 differentiation. Targeting of CD155 in immunization protocols using peptides may represent a promising new approach to boost protective humoral immunity in viral vaccines.

MeSH Terms
Adaptor Proteins, Vesicular Transport/metabolism Animals Antigens, Differentiation, T-Lymphocyte/genetics,metabolism CD4-Positive T-Lymphocytes/cytology,metabolism Cell Differentiation DNA Damage GATA3 Transcription Factor/metabolism Gene Expression Regulation/genetics,immunology Immunity, Humoral/genetics Ligands Mice Myeloid Differentiation Factor 88/metabolism Receptors, Virus/genetics,immunology Spleen/cytology,metabolism Th2 Cells/cytology,immunology,metabolism Toll-Like Receptor 3/genetics,immunology Viral Vaccines/immunology,metabolism
Chemicals
Adaptor Proteins, Vesicular Transport Antigens, Differentiation, T-Lymphocyte CD226 antigen GATA3 Transcription Factor Gata3 protein, mouse Ligands Myd88 protein, mouse Myeloid Differentiation Factor 88 Receptors, Virus TICAM-1 protein, mouse TLR3 protein, mouse Toll-Like Receptor 3 Viral Vaccines poliovirus receptor
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Kamran Neha
Immunology Programme, Department of Microbiology, National University of Singapore, Singapore, Singapore.
Takai Yoshimi
Miyoshi Jun
Biswas Subhra K
Wong Justin S B
Gasser Stephan
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Article Info
Journal
PloS one
Abbr.
PLoS One
ISSN
1932-6203
DOI
10.1371/journal.pone.0054406
Published
2013-00-00
Epub
2013-00-17
Pages
e54406
Language
English
Region
United States
NLM ID
101285081
PMCID
PMC3547938
Subset
IM
External Links
PubMed source DOI: 10.1371/journal.pone.0054406 PMC Full Text View journal details
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