Hemodialysis clearance of intravenously administered ribavirin.

Antimicrobial agents and chemotherapy ·Vol. 34 ·No. 3 ·1990-03-00 ·Pages 489-90

Kramer TH, Gaar GG, Ray CG, Minnich L, Copeland JG, Connor JD

Abstract

A patient with an implanted artificial heart, acute, anuric renal failure, and disseminated influenza virus type A infection received intravenous ribavirin. Drug elimination by hemodialysis was measured. Plasma dialysis clearance averaged 93.9 +/- 8.6 ml/min. The maximum amount of ribavirin removed from the body during one period of hemodialysis was 79.1 mg. Ribavirin is not removed in important quantities by hemodialysis.

MeSH Terms

Adult Female Heart, Artificial Humans Influenza A virus Influenza, Human/drug therapy Injections, Intravenous Renal Dialysis Ribavirin/administration & dosage,blood,pharmacokinetics Ribonucleosides/pharmacokinetics

Chemicals

Ribonucleosides Ribavirin

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Kramer T H

Department of Pharmacology, University of Arizona Health Sciences Center, Tucson 85724.

Gaar G G

Ray C G

Minnich L

Copeland J G

Connor J D

References (9)

9 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.34.3.489

Published

1990-03-00

Pages

489-90

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC171624

Subset

External Links

PubMed source DOI: 10.1128/AAC.34.3.489 PMC Full Text View journal details

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Hemodialysis clearance of intravenously administered ribavirin.

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