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PMID: 23256739 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The genetic basis for interindividual immune response variation to measles vaccine: new understanding and new vaccine approaches.

Expert review of vaccines ·Vol. 12 ·No. 1 ·2013-01-00 ·Pages 57-70

Haralambieva IH, Ovsyannikova IG, Pankratz VS, Kennedy RB, Jacobson RM, Poland GA

Abstract

The live-attenuated measles vaccine is effective, but measles outbreaks still occur in vaccinated populations. This warrants elucidation of the determinants of measles vaccine-induced protective immunity. Interindividual variability in markers of measles vaccine-induced immunity, including neutralizing antibody levels, is regulated in part by host genetic factor variations. This review summarizes recent advances in our understanding of measles vaccine immunogenetics relative to the perspective of developing better measles vaccines. Important genetic regulators of measles vaccine-induced immunity, such as HLA class I and HLA class II genotypes, single nucleotide polymorphisms in cytokine/cytokine receptor genes (IL12B, IL12RB1, IL2, IL10) and the cell surface measles virus receptor CD46 gene, have been identified and independently replicated. New technologies present many opportunities for identification of novel genetic signatures and genetic architectures. These findings help explain a variety of immune response-related phenotypes and promote a new paradigm of 'vaccinomics' for novel vaccine development.

MeSH Terms
Cytokines/genetics,immunology HLA Antigens/genetics,immunology Humans Immunity Immunogenetics Measles/genetics,immunology,prevention & control Measles Vaccine/administration & dosage,immunology Measles virus/immunology Polymorphism, Single Nucleotide
Chemicals
Cytokines HLA Antigens Measles Vaccine
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Haralambieva Iana H
Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.
Ovsyannikova Inna G
Pankratz V Shane
Kennedy Richard B
Jacobson Robert M
Poland Gregory A
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Article Info
Journal
Expert review of vaccines
Abbr.
Expert Rev Vaccines
ISSN
1744-8395
DOI
10.1586/erv.12.134
Published
2013-01-00
Pages
57-70
Language
English
Region
England
NLM ID
101155475
PMCID
PMC3570049
Subset
IM
Grants
NIAID NIH HHS · AI33144 · United States
NIAID NIH HHS · R01 AI033144 · United States
NIAID NIH HHS · R01 AI048793 · United States
NIAID NIH HHS · R37 AI048793 · United States
NIAID NIH HHS · AI48793 · United States
External Links
PubMed source DOI: 10.1586/erv.12.134 PMC Full Text View journal details
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