Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth.

Oncoimmunology ·Vol. 1 ·No. 8 ·2012-11-01 ·Pages 1433-1434

Fujimura T, Kambayashi Y, Aiba S

Abstract

Myeloid derived suppressor cells (MDSCa) are a heterogeneous population of cells that promote an immunosuppressive environment in tumor-bearing hosts. Recently, B7-H1 signaling has been reported to be critical for the maintainancer of regulatory T cells (Tregs), another immunosuppressive cell population. Here, we discuss the immunosuppressive function of B7-H1 on MDSCs, and the functional crosstalk between Tregs and MDSCs.

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Fujimura Taku

Department of Dermatology; Tohoku University Graduate School of Medicine; Sendai, Japan.

Kambayashi Yumi

Aiba Setsuya

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Article Info

Journal

Oncoimmunology

Abbr.

Oncoimmunology

ISSN

2162-4011

DOI

10.4161/onci.21176

Published

2012-11-01

Pages

1433-1434

Language

English

Region

United States

NLM ID

101570526

PMCID

PMC3518528

External Links

PubMed source DOI: 10.4161/onci.21176 PMC Full Text

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Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth.

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