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PMID: 23241849 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

RNase E: at the interface of bacterial RNA processing and decay.

Nature reviews. Microbiology ·Vol. 11 ·No. 1 ·2013-01-00 ·Pages 45-57

Mackie GA

Abstract

RNase E is an essential endonuclease that is abundant in many bacteria and plays an important part in all aspects of RNA metabolism. It functions as part of a large macromolecular complex known as the RNA degradosome. Recent evidence suggests that this complex associates with the inner membrane of bacteria, an observation that challenges traditional models in which soluble RNases are proposed to randomly interact with RNAs in the cytosol. In this Review, I summarize the major roles of RNase E in RNA processing and decay and discuss the various mechanisms that regulate its activity. I also propose a new model to rationalize the mechanism of RNase E action in the context of its localization in the bacterial cell.

MeSH Terms
Bacteria/enzymology Endoribonucleases/metabolism Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic Models, Biological Models, Molecular RNA Processing, Post-Transcriptional RNA Stability RNA, Bacterial/metabolism
Chemicals
RNA, Bacterial Endoribonucleases ribonuclease E
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Mackie George A
Department of Biochemistry and Molecular Biology, Life Sciences Centre, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. george.mackie@ubc.ca
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Article Info
Journal
Nature reviews. Microbiology
Abbr.
Nat Rev Microbiol
ISSN
1740-1534
DOI
10.1038/nrmicro2930
Email
george.mackie@ubc.ca
Published
2013-01-00
Pages
45-57
Language
English
Region
England
NLM ID
101190261
Subset
IM
Grants
Canadian Institutes of Health Research · Canada
External Links
PubMed source DOI: 10.1038/nrmicro2930 View journal details
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