Hello out there...is anybody listening?
Using a murine xenograft model system, Kuznetsov and colleagues show the existence of systemic interactions between a primary tumor and the growth of distal tumors in both homotypic and heterotypic tissues. Importantly, they show that the characteristics of the primary tumor govern the histologic features of the distal tumor through distinct pathways, thus providing novel opportunities for risk assessment, prognosis, prevention, and intervention.
8 references, click to expand
-
Systemic endocrine instigation of indolent tumor growth requires osteopontin.Cell. 2008 Jun 13;133(6):994-1005 PMID: 18555776
-
Cancer statistics, trends, and multiple primary cancer analyses from the Surveillance, Epidemiology, and End Results (SEER) Program.Oncologist. 2007 Jan;12(1):20-37 PMID: 17227898
-
Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials.Lancet. 2012 Apr 28;379(9826):1591-601 PMID: 22440947
-
Metastatic behavior of breast cancer subtypes.J Clin Oncol. 2010 Jul 10;28(20):3271-7 PMID: 20498394
-
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice.J Clin Invest. 2011 Feb;121(2):784-99 PMID: 21266779
-
Surgical removal of the primary tumor increases overall survival in patients with metastatic breast cancer: analysis of the 1988-2003 SEER data.Ann Surg Oncol. 2007 Aug;14(8):2187-94 PMID: 17522944
-
The role of aspirin in cancer prevention.Nat Rev Clin Oncol. 2012 Apr 03;9(5):259-67 PMID: 22473097
-
Identification of luminal breast cancers that establish a tumor-supportive macroenvironment defined by proangiogenic platelets and bone marrow-derived cells.Cancer Discov. 2012 Dec;2(12):1150-65 PMID: 22896036
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
