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题目:: Opportunities and methods for studying alternative splicing in cancer with RNA-Seq.
作者:: Feng(Huijuan),Qin(Zhiyi),Zhang(Xuegong)
状态:: 发布时间2013-11-18 , 更新时间 2015-11-19
期刊:: Cancer Lett
摘要:: The biogenesis, development and metastases of cancer are associated with many variations in the transcriptome. Alternative splicing of genes is a major post-transcriptional regulation mechanism that is involved in many types of cancer. The next-generation sequencing applied on RNAs (RNA-Seq) provides a new technology for studying transcriptomes. It provides an unprecedented opportunity for quantitatively studying alternative splicing in a systematic way. This mini-review summarizes the current RNA-Seq studies on cancer transcriptomes especially studies on cancer-related alternative splicing, and discusses the strategy for quantitative study of alternative splicing in cancers with RNA-Seq, the bioinformatics methods available and existing questions.
语言:: eng
DOI:: 10.1016/j.canlet.2012.11.010

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