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PMID: 23165185 Published · ppublish English Letter Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

The nature of confounding in genome-wide association studies.

Nature reviews. Genetics ·Vol. 14 ·No. 1 ·2013-01-00 ·Pages 1-2

Vilhjálmsson BJ, Nordborg M

Abstract

The authors argue that population structure per se is not a problem in genome-wide association studies - the true sources are the environment and the genetic background, and the latter is greatly underappreciated. They conclude that mixed models effectively address this issue.

MeSH Terms

Animals Confounding Factors, Epidemiologic Gene-Environment Interaction Genome-Wide Association Study Humans

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Vilhjálmsson Bjarni J

Harvard School of Public Health, Boston, Massachusetts 02115, USA. bvilhjal@hsph.harvard.edu

Nordborg Magnus

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Article Info

Journal

Nature reviews. Genetics

Abbr.

Nat Rev Genet

ISSN

1471-0064

DOI

10.1038/nrg3382

bvilhjal@hsph.harvard.edu

Published

2013-01-00

Epub

2012-00-20

Pages

1-2

Language

English

Region

England

NLM ID

100962779

Subset

Grants

NHGRI NIH HHS · HG002790 · United States

External Links

PubMed source DOI: 10.1038/nrg3382 View journal details

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The nature of confounding in genome-wide association studies.

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