AcSDKP, an inhibitor of CFU-S proliferation, is synthesized in mice under steady-state conditions and secreted by bone marrow in long-term culture.

Leukemia ·Vol. 4 ·No. 3 ·1990-03-00 ·Pages 235-7

Wdzieczak-Bakala J, Fache MP, Lenfant M, Frindel E, Sainteny F

Abstract

The peptide AcSDKP, isolated from fetal calf bone marrow, is able to prevent DNA synthesis in mouse CFU-S in vivo and in vitro. The molecule is demonstrated here to be constitutively produced in mice and synthesized by bone marrow cells in long term culture.

MeSH Terms

Animals Bone Marrow/metabolism Cell Division/drug effects Cells, Cultured Female Hematopoietic Stem Cells/drug effects Mice Mice, Inbred BALB C Oligopeptides/biosynthesis,metabolism

Chemicals

Oligopeptides goralatide

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Wdzieczak-Bakala J

INSERM U.250, Gustave-Roussy Institute, Villejuif, France.

Fache M P

Lenfant M

Frindel E

Sainteny F

Article Info

Journal

Leukemia

Abbr.

Leukemia

ISSN

0887-6924

Published

1990-03-00

Pages

235-7

Language

English

Region

England

NLM ID

8704895

Subset

External Links

PubMed source View journal details

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AcSDKP, an inhibitor of CFU-S proliferation, is synthesized in mice under steady-state conditions and secreted by bone marrow in long-term culture.

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