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PMID: 2312505 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Opposite effects of monokines (interleukin-1 and tumor necrosis factor) on proliferation and heparin-binding (fibroblast) growth factor binding to human aortic endothelial and smooth muscle cells.

In vitro cellular & developmental biology : journal of the Tissue Culture Association ·Vol. 26 ·No. 2 ·1990-02-00 ·Pages 213-6

Sawada H, Kan M, McKeehan WL

Abstract

Heparin-binding (fibroblast) growth factors (HBGF) are mitogens for both human aortic endothelial and smooth muscle cells. Under similar conditions, both vascular cells display similar numbers of specific HBGF binding sites with similar apparent affinity for HBGF. The monokines, interleukin-1 and tumor necrosis factor, inhibit endothelial cell growth and stimulate smooth muscle cell growth. The opposite mitogenic effects correlate with reduction and increase in HBGF receptor number displayed by endothelial and smooth muscle cells, respectively. These results suggest that the two monokines may depress endothelial cell regeneration and augment smooth muscle cell hyperplasia by differential modulation of the HBGF receptor in the two vascular cell types.

MeSH Terms
Aorta/cytology,metabolism,ultrastructure Cell Division/drug effects Cells, Cultured Endothelium, Vascular/cytology,metabolism,ultrastructure Growth Substances/metabolism Heparin/metabolism Humans Hyperplasia/metabolism,pathology Interleukin-1/pharmacology Monokines/pharmacology Muscle, Smooth, Vascular/cytology,metabolism,ultrastructure Receptors, Mitogen/drug effects,metabolism Receptors, Vascular Endothelial Growth Factor Tumor Necrosis Factor-alpha/pharmacology
Chemicals
Growth Substances Interleukin-1 Monokines Receptors, Mitogen Tumor Necrosis Factor-alpha Heparin Receptors, Vascular Endothelial Growth Factor
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sawada H
W. Alton Jones Cell Science Center, Inc., Lake Placid, New York 12946.
Kan M
McKeehan W L
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Article Info
Journal
In vitro cellular & developmental biology : journal of the Tissue Culture Association
Abbr.
In Vitro Cell Dev Biol
ISSN
0883-8364
DOI
10.1007/BF02624115
Published
1990-02-00
Pages
213-6
Language
English
Region
United States
NLM ID
8506951
Subset
IM
Grants
NIDDK NIH HHS · DK35310 · United States
NHLBI NIH HHS · HL33487 · United States
External Links
PubMed source DOI: 10.1007/BF02624115
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