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题目:: Suppression of hepatocarcinoma model in vitro and in vivo by ECRG2 delivery using adenoviral vector.
作者:: Song(H),Song(C),Wang(H),Li(C),Yang(F),Lu(S-H),Lin(C),Zhan(Q),Wang(X),Qian(H)
状态:: 发布时间2012-11-15 , 更新时间 2012-11-15
期刊:: Cancer Gene Ther
摘要:: Hepatocarcinoma represents one of the most malignant cancer types. Esophageal cancer-related gene 2 (ECRG2) is found to be critical in the process of carcinogenesis. It regulates urokinase-type plasmin activator receptor and extracellular matrix function and its polymorphism in exon 4 is associated with cancer relapse. To explore new strategies to fight against cancer, here we first systematically evaluated the therapeutic potential as a biological tool using adenoviral vector (Ad-ECRG2). Ad-ECRG2 is exogenously expressed in cytoplasm and is potent to suppress the growth of cancer cell by inducing apoptosis as effective as Ad-p53. Ad-ECRG2 is able to suppress the invasion and adhesion of cancer cells at low titers. It alters the expression of a panel of cancer-related molecules, including nuclear factor-kB, matrix metalloproteinase 2 and E-cadherin, contributing to reverse malignancy phenotype of cancer cells. In vivo experiments show a significant inhibition of cancer growth by intratumoral Ad-ECRG2 administration. No evident toxicity was observed in the model animal during the study. We concluded that ECRG2 is a potential molecular target in biological therapy strategies for cancer treatment.
语言:: eng
DOI:: 10.1038/cgt.2012.77

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