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PMID: 23049548 Published · ppublish English Journal Article

Probiotics, prebiotics, and synbiotics: gut and beyond.

Gastroenterology research and practice ·Vol. 2012 ·2012-00-00 ·Pages 872716

Vyas U, Ranganathan N

Abstract

The human intestinal tract has been colonized by thousands of species of bacteria during the coevolution of man and microbes. Gut-borne microbes outnumber the total number of body tissue cells by a factor of ten. Recent metagenomic analysis of the human gut microbiota has revealed the presence of some 3.3 million genes, as compared to the mere 23 thousand genes present in the cells of the tissues in the entire human body. Evidence for various beneficial roles of the intestinal microbiota in human health and disease is expanding rapidly. Perturbation of the intestinal microbiota may lead to chronic diseases such as autoimmune diseases, colon cancers, gastric ulcers, cardiovascular disease, functional bowel diseases, and obesity. Restoration of the gut microbiota may be difficult to accomplish, but the use of probiotics has led to promising results in a large number of well-designed (clinical) studies. Microbiomics has spurred a dramatic increase in scientific, industrial, and public interest in probiotics and prebiotics as possible agents for gut microbiota management and control. Genomics and bioinformatics tools may allow us to establish mechanistic relationships among gut microbiota, health status, and the effects of drugs in the individual. This will hopefully provide perspectives for personalized gut microbiota management.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Vyas Usha
Kibow Biotech Inc., Newtown Business Center, 4781 West Chester Pike, Newtown Square, PA 19073, USA.
Ranganathan Natarajan
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Article Info
Journal
Gastroenterology research and practice
Abbr.
Gastroenterol Res Pract
ISSN
1687-630X
DOI
10.1155/2012/872716
Published
2012-00-00
Epub
2012-00-19
Pages
872716
Language
English
Region
Egypt
NLM ID
101475557
PMCID
PMC3459241
External Links
PubMed source DOI: 10.1155/2012/872716 PMC Full Text View journal details
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