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题目:: Identifying the stem cell of the intestinal crypt: strategies and pitfalls.
作者:: Barker(Nick),van Oudenaarden(Alexander),Clevers(Hans)
状态:: 发布时间2012-10-08 , 更新时间 2016-05-18
期刊:: Cell Stem Cell
摘要:: Decades ago, two nonoverlapping crypt stem cell populations were proposed: Leblond's Crypt Base Columnar (CBC) cell and Potten's +4 cell. The identification of CBC markers including Lgr5 has confirmed Leblond's predictions that CBC cells are anatomically distinct, long-lived stem cells that permanently cycle. While Potten originally described +4 cells as proliferative and unusually radiation-sensitive, recent efforts to identify +4 stem cells have focused on the identification of cells that are quiescent and radiation-resistant. Here, we describe commonalities and discrepancies between the individual studies and discuss challenges of marker-based lineage tracing.
语言:: eng
DOI:: 10.1016/j.stem.2012.09.009

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