Order from chaos: single cell reprogramming in two phases.
作者:
Pan(Guangjin),Pei(Duanqing)
状态:
发布时间2012-10-08
, 更新时间 2016-05-18
期刊:
Cell Stem Cell
摘要:
The generation of induced pluripotent stem cells (iPSCs) is considered to be stochastic with a minute fraction of cells becoming pluripotent. Recently in Cell, Buganim et al. (2012) changed this view using single cell analyses to reveal a stochastic early and hierarchical late phase, with implications for productive alternative reprogramming strategies.