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PMID: 2296584 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Inhibition by Ca2+ of inositol trisphosphate-mediated Ca2+ liberation: a possible mechanism for oscillatory release of Ca2+.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 87 ·No. 1 ·1990-01-00 ·Pages 260-4

Parker I, Ivorra I

Abstract

Light-flash photolysis of caged inositol 1,4,5-trisphosphate (InsP3) was used to generate reproducible transients of free InsP3 in Xenopus oocytes, and the resulting liberation of Ca2+ from intracellular stores was monitored by recording Ca2+-activated membrane currents and by use of the fluorescent Ca2+ indicator fluo-3. InsP3-mediated Ca2+ release was inhibited by elevating the intracellular free Ca2+ level, either by microinjecting Ca2+ into the cell or by applying conditioning light flashes to liberate Ca2+. This inhibition followed a slow time course, being maximal after about 2 s and subsequently declining over several seconds. Negative feedback of Ca2+ ions on InsP3-mediated Ca2+ liberation may explain the oscillatory release of Ca2+ seen during activation of inositol phospholipid signaling in the oocyte, and the time course of the inhibition is consistent with the period of the oscillations.

MeSH Terms
Activity Cycles Animals Calcium/pharmacology,physiology Cell Membrane/drug effects,physiology Electric Conductivity Female Inositol 1,4,5-Trisphosphate/physiology Kinetics Membrane Potentials/radiation effects Oocytes/drug effects,physiology,radiation effects Photolysis Second Messenger Systems Time Factors Ultraviolet Rays Xenopus laevis
Chemicals
Inositol 1,4,5-Trisphosphate Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Parker I
Department of Psychobiology, University of California, Irvine 92715.
Ivorra I
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29 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.87.1.260
Published
1990-01-00
Pages
260-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC53242
Subset
IM
Grants
NIGMS NIH HHS · GM39831 · United States
NINDS NIH HHS · NS23284 · United States
External Links
PubMed source DOI: 10.1073/pnas.87.1.260 PMC Full Text View journal details
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