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题目:: Basics and applications of stem cells in the pancreas.
作者:: Sekine(Keisuke),Taniguchi(Hideki)
状态:: 发布时间2012-11-16 , 更新时间 2016-05-11
期刊:: J Hepatobiliary Pancreat Sci
摘要:: Enormous efforts have been made to establish pancreatic stem/progenitor cells as a source for regenerative medicine for the treatment of diabetes mellitus. In recent years, it has been recognized that the self-renewal of beta cells is the dominant process involved in postnatal beta-cell regeneration and expansion. Nevertheless, several in-vitro studies have suggested that ductal or as yet unidentified cells are candidates for pancreatic stem/progenitor cells that can differentiate into multilineage cells, including insulin(+) cells. The question remains as to whether beta cells are generated postnatally from stem/progenitor cells other than pre-existing beta cells. Furthermore, mutated pancreatic stem cells are considered to be prospective candidates for cancer stem cells or tumor-initiating cells. This review highlights recent progress in pancreatic stem/progenitor cell research.
语言:: eng
DOI:: 10.1007/s00534-012-0545-3

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