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PMID: 22960632 Published · ppublish English Journal Article Comment

RING-between-RINGs--keeping the safety on loaded guns.

The EMBO journal ·Vol. 31 ·No. 19 ·2012-10-03 ·Pages 3792-4

Dove KK, Klevit RE

Abstract

暂无摘要

MeSH Terms
Carrier Proteins/metabolism Humans Ubiquitin/metabolism Ubiquitin-Protein Ligases/metabolism
Chemicals
Carrier Proteins Ubiquitin RNF31 protein, human Ubiquitin-Protein Ligases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dove Katja K
Department of Biochemistry, University of Washington, Seattle, WA, USA.
Klevit Rachel E
References (16)
16 references, click to expand
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    Nature. 2011 Mar 31;471(7340):633-6 PMID: 21455180
  2. Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation.
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  3. UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.
    Nature. 2011 Jun 2;474(7349):105-8 PMID: 21532592
  4. A non-canonical UBA-UBL interaction forms the linear-ubiquitin-chain assembly complex.
    EMBO Rep. 2012 May 01;13(5):462-8 PMID: 22430200
  5. Identification of an unconventional E3 binding surface on the UbcH5 ~ Ub conjugate recognized by a pathogenic bacterial E3 ligase.
    Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2848-53 PMID: 20133640
  6. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.
    Open Biol. 2012 May;2(5):120080 PMID: 22724072
  7. Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.
    Nat Cell Biol. 2009 Feb;11(2):123-32 PMID: 19136968
  8. SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.
    Nature. 2011 Mar 31;471(7340):637-41 PMID: 21455181
  9. The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.
    EMBO J. 2012 Oct 3;31(19):3833-44 PMID: 22863777
  10. Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation.
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  12. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages.
    Nat Struct Mol Biol. 2007 Oct;14(10):941-8 PMID: 17873885
  13. Structure and function of a HECT domain ubiquitin-binding site.
    EMBO Rep. 2011 Apr;12(4):334-41 PMID: 21399621
  14. LUBAC synthesizes linear ubiquitin chains via a thioester intermediate.
    EMBO Rep. 2012 Sep;13(9):840-6 PMID: 22791023
  15. A ubiquitin ligase complex assembles linear polyubiquitin chains.
    EMBO J. 2006 Oct 18;25(20):4877-87 PMID: 17006537
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
1460-2075
DOI
10.1038/emboj.2012.260
Published
2012-10-03
Epub
2012-00-07
Pages
3792-4
Language
English
Region
England
NLM ID
8208664
PMCID
PMC3463855
Subset
IM
Grants
NIGMS NIH HHS · R01 GM088055 · United States
Corrections
CommentOn
PMID: 22863777
External Links
PubMed source DOI: 10.1038/emboj.2012.260 PMC Full Text View journal details
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