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PMID: 22952391 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Treg cells, life history, and diversity.

Cold Spring Harbor perspectives in biology ·Vol. 4 ·No. 9 ·2012-09-01 ·Pages a007021

Benoist C, Mathis D

Abstract

Regulatory T cells expressing the FoxP3 transcription factor have a profound and nonredundant role in several aspects of immunological tolerance. We will review here the specification of this lineage, its population dynamics, and the diversity of subphenotypes that correlate with their diverse roles in controlling inflammation in a variety of settings.

MeSH Terms
Animals Cell Differentiation Cell Lineage Forkhead Transcription Factors/metabolism,physiology Humans Immune Tolerance Phenotype T-Lymphocytes, Regulatory/cytology,immunology,metabolism
Chemicals
FOXP3 protein, human Forkhead Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Benoist Christophe
Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Mathis Diane
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Article Info
Journal
Cold Spring Harbor perspectives in biology
Abbr.
Cold Spring Harb Perspect Biol
ISSN
1943-0264
DOI
10.1101/cshperspect.a007021
Published
2012-09-01
Epub
2012-00-01
Pages
a007021
Language
English
Region
United States
NLM ID
101513680
PMCID
PMC3428763
Subset
IM
Grants
NIAID NIH HHS · R01 AI051530 · United States
NIDDK NIH HHS · R01 DK092541 · United States
NIDDK NIH HHS · R01-DK92541 · United States
NIAID NIH HHS · R01-AI51530 · United States
External Links
PubMed source DOI: 10.1101/cshperspect.a007021 PMC Full Text View journal details
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