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PMID: 22945800 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness.

Cellular and molecular life sciences : CMLS ·Vol. 69 ·No. 20 ·2012-10-00 ·Pages 3429-56

Sánchez-Tilló E, Liu Y, de Barrios O, Siles L, Fanlo L, Cuatrecasas M, Darling DS, Dean DC, Castells A, Postigo A

Abstract

Cancer is a complex multistep process involving genetic and epigenetic changes that eventually result in the activation of oncogenic pathways and/or inactivation of tumor suppressor signals. During cancer progression, cancer cells acquire a number of hallmarks that promote tumor growth and invasion. A crucial mechanism by which carcinoma cells enhance their invasive capacity is the dissolution of intercellular adhesions and the acquisition of a more motile mesenchymal phenotype as part of an epithelial-to-mesenchymal transition (EMT). Although many transcription factors can trigger it, the full molecular reprogramming occurring during an EMT is mainly orchestrated by three major groups of transcription factors: the ZEB, Snail and Twist families. Upregulated expression of these EMT-activating transcription factors (EMT-ATFs) promotes tumor invasiveness in cell lines and xenograft mice models and has been associated with poor clinical prognosis in human cancers. Evidence accumulated in the last few years indicates that EMT-ATFs also regulate an expanding set of cancer cell capabilities beyond tumor invasion. Thus, EMT-ATFs have been shown to cooperate in oncogenic transformation, regulate cancer cell stemness, override safeguard programs against cancer like apoptosis and senescence, determine resistance to chemotherapy and promote tumor angiogenesis. This article reviews the expanding portfolio of functions played by EMT-ATFs in cancer progression.

MeSH Terms
Activating Transcription Factors/metabolism Animals Cell Transformation, Neoplastic/pathology Epithelial-Mesenchymal Transition Humans Mice Neoplasm Invasiveness Neoplasms/metabolism,pathology
Chemicals
Activating Transcription Factors
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Sánchez-Tilló Ester
Group of Transcriptional Regulation of Gene Expression, Department of Oncology and Hematology, IDIBAPS, Barcelona, Spain.
Liu Yongqing
de Barrios Oriol
Siles Laura
Fanlo Lucia
Cuatrecasas Miriam
Darling Douglas S
Dean Douglas C
Castells Antoni
Postigo Antonio
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Article Info
Journal
Cellular and molecular life sciences : CMLS
Abbr.
Cell Mol Life Sci
ISSN
1420-9071
DOI
10.1007/s00018-012-1122-2
Published
2012-10-00
Epub
2012-00-04
Pages
3429-56
Language
English
Region
Switzerland
NLM ID
9705402
Subset
IM
External Links
PubMed source DOI: 10.1007/s00018-012-1122-2 View journal details
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