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题目:: Incidences of overall and site specific cancers in TNFα inhibitor treated patients with rheumatoid arthritis and other arthritides - a follow-up study from the DANBIO Registry.
作者:: Dreyer(Lene),Mellemkjær(Lene),Andersen(Anne Rødgaard),Bennett(Philip),Poulsen(Uta Engling),Juulsgaard Ellingsen(Torkell),Hansen(Torben Høiland),Jensen(Dorte Vendelbo),Linde(Louise),Lindegaard(Hanne Merete),Loft(Anne Gitte Rasmussen),Nordin(Henrik),Omerovic(Emina),Rasmussen(Claus),Schlemmer(Annette),Tarp(Ulrik),Hetland(Merete Lund)
状态:: 发布时间2012-12-13 , 更新时间 2012-12-13
期刊:: Ann Rheum Dis
摘要:: To investigate the incidence of cancer in arthritis patients treated with or without TNFα inhibitors (TNF-I).,Arthritis patients from the DANBIO database were followed-up for cancer in the Danish Cancer Registry during 2000-2008.,Hazard ratio for cancer overall was 1.02 (95% confidence interval (CI) 0.80-1.30) in 3347 TNF-I-treated RA patients compared to non-treated. Excess among TNF-I-treated was found for colon cancer (HR 3.52 (95%CI 1.11-11.15), whereas 6 and 0 ovarian cancer cases were observed in treated and non-treated patients, respectively. Compared to the general population, TNF-I-treated RA patients had increased risk for cancer overall, cancer in lymphatic-haematopoietic tissue and non-melanoma skin cancer, while non-RA patients had no increase in overall cancer risk.,Our results suggest that TNF-I therapy in routine care is not associated with an overall excess of cancer in arthritis patients, but observed increased risks of colon and ovarian cancer need further investigation.
语言:: eng
DOI:: 10.1136/annrheumdis-2012-201969

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