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PMID: 22944726 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Cadherins in collective cell migration of mesenchymal cells.

Current opinion in cell biology ·Vol. 24 ·No. 5 ·2012-10-00 ·Pages 677-84

Theveneau E, Mayor R

Abstract

Immunity, embryogenesis and tissue repair rely heavily on cell migration. Cells can be seen migrating as individuals or large groups. In the latter case, collectiveness emerges via cell-cell interactions. In migratory epithelial cell sheets, classic Cadherins are critical to maintain tissue integrity, to promote coordination and establish cell polarity. However, recent evidence indicates that mesenchymal cells, migrating in streams such as neural crest or cancer cells, also exhibit collective migration. Here we will explore the idea that Cadherins play an essential role during collective migration of mesenchymal cells.

MeSH Terms
Animals Cadherins/metabolism Cell Adhesion Cell Movement Cell Polarity Mesoderm/cytology,metabolism Neural Crest/cytology
Chemicals
Cadherins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Theveneau Eric
Department of Cell and Developmental Biology, University College London, UK.
Mayor Roberto
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
1879-0410
DOI
10.1016/j.ceb.2012.08.002
Published
2012-10-00
Epub
2012-00-01
Pages
677-84
Language
English
Region
England
NLM ID
8913428
PMCID
PMC4902125
Subset
IM
Grants
Medical Research Council · MR/J000655/1 · United Kingdom
Medical Research Council · MR/M010465/1 · United Kingdom
Wellcome Trust · United Kingdom
Biotechnology and Biological Sciences Research Council · United Kingdom
External Links
PubMed source DOI: 10.1016/j.ceb.2012.08.002 PMC Full Text View journal details
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