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PMID: 22937212 Published · ppublish English Journal Article

Krüppel-like factor 8 emerges as an important regulator of cancer.

American journal of translational research ·Vol. 4 ·No. 3 ·2012-00-00 ·Pages 357-63

Lahiri SK, Zhao J

Abstract

Krüppel-like factor 8 (KLF8) is a young member of the KLF transcription factor family proteins. It is highly overexpressed in several types of human cancers and regulates various cellular processes important for tumor progression. Increasing evidence has made KLF8 a new focus in cancer research and a potential target for cancer therapy. This review highlights the role of KLF8 in cancer by summarizing the up-to-date studies into its structure, function as a dual transcription factor, target genes and mechanisms of expression and modifications.

Keywords
Keywords: Krüppel-like factor 8 (KLF8) cancer
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lahiri Satadru K
Zhao Jihe
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31 references, click to expand
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Article Info
Journal
American journal of translational research
Abbr.
Am J Transl Res
ISSN
1943-8141
Published
2012-00-00
Epub
2012-00-27
Pages
357-63
Language
English
Region
United States
NLM ID
101493030
PMCID
PMC3426389
Grants
NCI NIH HHS · R01 CA132977 · United States
External Links
PubMed source PMC Full Text View journal details
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