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题目:: [Secretion of prostaglandin E by cells of human thymoma MOLT-4 and their sensitivity to cytotoxic action of NK-cells].
作者:: Kliuchareva(T E),Matveeva(V A),Kushlinskiĭ(N E),Uvarova(E N)
状态:: 发布时间1991-04-09 , 更新时间 2013-11-21
期刊:: Biull Eksp Biol Med
摘要:: It was demonstrated that thymoma cells of MOLT-4 strain which are the standard cell targets of cytotoxic tests (CT) with NK-cells are rapidly releasing PGE in contact with NK-cells; as a consequence the depression of cytotoxic activity (CTA) of NK-cells takes place. The significant decrease of CTA of NK-cells was observed when the absolute number of MOLT-4 target cells participating in CT increased. Correspondingly the susceptibility of MOLT-4 cells as a target in CT is decreased. The levels of susceptibility of MOLT-4 cells to NK-cell cytotoxicity and CTA of NK-cells retained, or even increased, after the pretreatment of MOLT-4 cells with indomethacin.
语言:: rus
DOI:

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