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PMID: 2281134 Published · ppublish English Journal Article Review

Induction, repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells.

Radiation and environmental biophysics ·Vol. 29 ·No. 4 ·1990-00-00 ·Pages 273-92

Frankenberg-Schwager M

Abstract

This report summarizes data on the induction, repair and biological relevance of five types of radiation-induced DNA lesions for which repair kinetic studies have been performed in eukaryotic cells by various laboratories. These lesions are: DNA-protein crosslinks, base damage, single-strand breaks, double-strand breaks and bulky lesions (clustered base damage in the nm-range). The influence of various factors, such as oxia/anoxia, linear energy transfer of the radiation used, incubation medium, cell cycle stage, thiol content, hyperthermia, on the induction and repair of these lesions is described. Radiation-sensitive cell lines are also included.

MeSH Terms
Animals DNA/radiation effects DNA Repair/physiology DNA, Single-Stranded/radiation effects DNA-Binding Proteins/metabolism,radiation effects Eukaryotic Cells/physiology,radiation effects Nucleotides/radiation effects
Chemicals
DNA, Single-Stranded DNA-Binding Proteins Nucleotides DNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Frankenberg-Schwager M
Gesellschaft für Strahlen- und Umweltforschung mbH, Institut für Biophysikalische Strahlenforschung, Frankfurt, Federal Republic of Germany.
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Article Info
Journal
Radiation and environmental biophysics
Abbr.
Radiat Environ Biophys
ISSN
0301-634X
DOI
10.1007/BF01210408
Published
1990-00-00
Pages
273-92
Language
English
Region
Germany
NLM ID
0415677
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01210408 View journal details
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