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PMID: 22806925 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The role of endothelial-mesenchymal transition in heterotopic ossification.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research ·Vol. 27 ·No. 8 ·2012-08-00 ·Pages 1619-22

Medici D, Olsen BR

Abstract

Heterotopic ossification (HO) is a process by which bone forms in soft tissues, in response to injury, inflammation, or genetic disease. This usually occurs by initial cartilage formation, followed by endochondral ossification. A rare disease called fibrodysplasia ossificans progressiva (FOP) allows this mechanism to be induced by a combination of genetic mutation and acute inflammatory responses. FOP patients experience progressive HO throughout their lifetime and form an ectopic skeleton. Recent studies on FOP have suggested that heterotopic cartilage and bone is of endothelial origin. Vascular endothelial cells differentiate into skeletal cells through a mesenchymal stem cell intermediate that is generated by endothelial-mesenchymal transition (EndMT). Local inflammatory signals and/or other changes in the tissue microenvironment mediate the differentiation of endothelial-derived mesenchymal stem cells into chondrocytes and osteoblasts to induce HO. We discuss the current evidence for the endothelial contribution to heterotopic bone formation.

MeSH Terms
Animals Endothelium/pathology Humans Mesoderm/pathology Models, Biological Ossification, Heterotopic/pathology,therapy
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Medici Damian
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. damian_medici@hms.harvard.edu
Olsen Bjorn R
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Article Info
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Abbr.
J Bone Miner Res
ISSN
1523-4681
DOI
10.1002/jbmr.1691
Email
damian_medici@hms.harvard.edu
Published
2012-08-00
Epub
2012-00-02
Pages
1619-22
Language
English
Region
United States
NLM ID
8610640
PMCID
PMC3432417
Subset
IM
Grants
NIAMS NIH HHS · P01 AR048564 · United States
NIAMS NIH HHS · R01 AR036819 · United States
NIAMS NIH HHS · P01AR048564 · United States
NHLBI NIH HHS · R01HL112860 · United States
NHLBI NIH HHS · R01 HL112860 · United States
NIGMS NIH HHS · P20 GM104937 · United States
External Links
PubMed source DOI: 10.1002/jbmr.1691 PMC Full Text View journal details
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