Localization of the structural domain responsible for the chemotactic properties of thrombin on polymorphonuclear leukocytes.

Thrombosis research ·Vol. 60 ·No. 1 ·1990-10-01 ·Pages 33-42

Morin A, Arvier MM, Doutremepuich F, Vigneron C

Abstract

Human alpha thrombin at 1.1.10(-5) M is chemotactic for human polymorphonuclear leukocytes. This thrombin property disappears when the alpha thrombin (1.1.10(-5) M) hirudin (1.32.10(-5) M) mixture is realized. The same result is obtained when the thrombin at 1.1. 10(-5) M is inhibited by antithrombin III in a ratio of 1 mol of thrombin for 4.5 mol of antithrombin III. The hirudin and the antithrombin III appear therefore to mask, by their binding the structural domain responsible for the chemotactic properties of thrombin on polymorphonuclear leukocytes.

MeSH Terms

Antithrombin III/pharmacology Binding Sites Chemotactic Factors/antagonists & inhibitors,chemistry,physiology Hirudins/pharmacology Humans In Vitro Techniques Models, Molecular Molecular Structure Neutrophils/drug effects,physiology Thrombin/antagonists & inhibitors,chemistry,physiology

Chemicals

Chemotactic Factors Hirudins Antithrombin III Thrombin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Morin A

Centre de Transfusion sanguine, Vandoeuvre, France.

Arvier M M

Doutremepuich F

Vigneron C

Article Info

Journal

Thrombosis research

Abbr.

Thromb Res

ISSN

0049-3848

DOI

10.1016/0049-3848(90)90337-c

Published

1990-10-01

Pages

33-42

Language

English

Region

United States

NLM ID

0326377

Subset

External Links

PubMed source DOI: 10.1016/0049-3848(90)90337-c View journal details

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Localization of the structural domain responsible for the chemotactic properties of thrombin on polymorphonuclear leukocytes.

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