| GeneLibs

题目:: Expansion of follicular helper T cells in the absence of Treg cells: implications for loss of B-cell anergy.
作者:: Leonardo(Steven M),De Santis(Jessica L),Gehrand(Ashley),Malherbe(Laurent P),Gauld(Stephen B)
状态:: 发布时间2012-10-08 , 更新时间 2012-10-08
期刊:: Eur J Immunol
摘要:: The maintenance of B-cell anergy is essential to prevent the production of autoantibodies and autoimmunity. However, B-cell extrinsic mechanisms that regulate B-cell anergy remain poorly understood. We previously demonstrated that regulatory T (Treg) cells are necessary for the maintenance of B-cell anergy. We now show that in Treg-cell-deficient mice, helper T cells are necessary and sufficient for loss of B-cell tolerance/anergy. In addition, we show that the absence of Treg cells is associated with an increase in the proportion of CD4(+) cells that express GL7 and correlated with an increase in germinal center follicular helper T (GC-T(FH) ) cells. These GC-T(FH) cells, but not those from Treg-cell-sufficient hosts, were sufficient to drive antibody production by anergic B cells. We propose that a function of Treg cells is to prevent the expansion of T(FH) cells, especially GC-T(FH) cells, which support autoantibody production.
语言:: eng
DOI:: 10.1002/eji.201242616

文献库文献相关信息