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PMID: 22722480 Published · ppublish English Journal Article

Elucidating the temporal order of silencing.

EMBO reports ·Vol. 13 ·No. 8 ·2012-08-00 ·Pages 662-3

Izaurralde E

Abstract

暂无摘要

MeSH Terms
Animals Drosophila melanogaster/genetics Gene Silencing Humans Models, Genetic RNA Stability/genetics RNA, Messenger/genetics,metabolism Time Factors Zebrafish/genetics
Chemicals
RNA, Messenger
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Izaurralde Elisa
Department of Biochemistry, Max Planck Institute for Developmental Biology, Tübingen, Germany. elisa.izaurralde@tuebingen.mpg.de
References (12)
12 references, click to expand
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  2. A parsimonious model for gene regulation by miRNAs.
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    Science. 2012 Apr 13;336(6078):233-7 PMID: 22422859
  4. Mammalian microRNAs predominantly act to decrease target mRNA levels.
    Nature. 2010 Aug 12;466(7308):835-40 PMID: 20703300
  5. GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.
    Mol Cell. 2011 Oct 7;44(1):120-33 PMID: 21981923
  6. Widespread changes in protein synthesis induced by microRNAs.
    Nature. 2008 Sep 4;455(7209):58-63 PMID: 18668040
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    Nat Rev Genet. 2011 Feb;12(2):99-110 PMID: 21245828
  8. The impact of microRNAs on protein output.
    Nature. 2008 Sep 4;455(7209):64-71 PMID: 18668037
  9. miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs.
    Nat Struct Mol Biol. 2011 Oct 07;18(11):1218-26 PMID: 21984184
  10. Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs.
    Science. 2006 Apr 7;312(5770):75-9 PMID: 16484454
  11. Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells.
    EMBO Rep. 2012 Aug;13(8):716-23 PMID: 22677978
  12. miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.
    Nat Struct Mol Biol. 2011 Oct 07;18(11):1211-7 PMID: 21984185
Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-3178
DOI
10.1038/embor.2012.91
Email
elisa.izaurralde@tuebingen.mpg.de
Published
2012-08-00
Epub
2012-00-22
Pages
662-3
Language
English
Region
England
NLM ID
100963049
PMCID
PMC3410391
Subset
IM
External Links
PubMed source DOI: 10.1038/embor.2012.91 PMC Full Text View journal details
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