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PMID: 226889 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication.

Nature ·Vol. 281 ·No. 5731 ·1979-10-11 ·Pages 456-61

Liu LF, Liu CC, Alberts BM

Abstract

A novel ATP-dependent DNA topoisomerase which makes reversible double-strand breaks in the DNA double helix has been purified to near homogeneity from T4 bacteriophage-infected Escherichia coli cells. Genetic data suggest that this activity is essential for initiating T4 DNA replication forks in vivo.

MeSH Terms
Adenosine Triphosphate/metabolism DNA Replication DNA Topoisomerases, Type I/isolation & purification,metabolism DNA, Superhelical/metabolism Genes Genes, Viral Mutation RNA/metabolism T-Phages/enzymology,genetics Virus Replication
Chemicals
DNA, Superhelical RNA Adenosine Triphosphate DNA Topoisomerases, Type I
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Liu L F
Liu C C
Alberts B M
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/281456a0
Published
1979-10-11
Pages
456-61
Language
English
Region
England
NLM ID
0410462
Subset
IM
External Links
PubMed source DOI: 10.1038/281456a0 View journal details
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