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PMID: 22684455 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Comment

miR-23a, a critical regulator of "migR"ation and metastasis in colorectal cancer.

Cancer discovery ·Vol. 2 ·No. 6 ·2012-06-00 ·Pages 489-91

Wang Z, Wei W, Sarkar FH

Abstract

Jahid and colleagues have shown that miR-23a promotes the transition from indolent to invasive colorectal cancer through inhibition of the MTSS1 tumor suppressor. This study reveals a novel role of miR-23a in the acceleration of colorectal cancer progression.

MeSH Terms

Adenocarcinoma/genetics Adenoma/genetics Animals Colorectal Neoplasms/genetics Humans MicroRNAs/genetics

Chemicals

MicroRNAs Mirn23b microRNA, mouse

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Wang Zhiwei

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Wei Wenyi

Sarkar Fazlul H

References (11)

11 references, click to expand

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Article Info

Journal

Cancer discovery

Abbr.

Cancer Discov

ISSN

2159-8290

DOI

10.1158/2159-8290.CD-12-0177

Published

2012-06-00

Pages

489-91

Language

English

Region

United States

NLM ID

101561693

PMCID

PMC3375870

Subset

Grants

NCI NIH HHS · R01 CA131151 · United States

NIGMS NIH HHS · GM094777 · United States

NCI NIH HHS · 1R01CA132794 · United States

NIGMS NIH HHS · GM089763 · United States

NCI NIH HHS · R01 CA108535 · United States

NIGMS NIH HHS · R01 GM089763 · United States

NCI NIH HHS · 1R01CA154321 · United States

NCI NIH HHS · 5R01CA131151 · United States

NIGMS NIH HHS · R01 GM094777 · United States

NCI NIH HHS · R01 CA154321 · United States

NCI NIH HHS · R01 CA132794 · United States

NCI NIH HHS · R01 CA083695 · United States

Corrections

CommentOn

PMID: 22628407

External Links

PubMed source DOI: 10.1158/2159-8290.CD-12-0177 PMC Full Text View journal details

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miR-23a, a critical regulator of "migR"ation and metastasis in colorectal cancer.

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