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题目:: Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells.
作者:: León(Beatriz),Ballesteros-Tato(André),Browning(Jeffrey L),Dunn(Robert),Randall(Troy D),Lund(Frances E)
状态:: 发布时间2012-06-20 , 更新时间 2016-10-19
期刊:: Nat Immunol
摘要:: Although cognate encounters between antigen-bearing dendritic cells (DCs) that express the chemokine receptor CCR7 and CCR7(+) naive T cells take place in the T cell zone of lymph nodes, it is unknown whether the colocalization of DCs and T cells in the T cell area is required for the generation of effector cells. Here we found that after infection with an intestinal nematode, antigen-bearing DCs and CD4(+) T cells upregulated the chemokine receptor CXCR5 and localized together outside the T cell zone by a mechanism dependent on the chemokine CXCL13, B cells and lymphotoxin. Notably, lymphotoxin-expressing B cells, CXCR5-expressing DCs and T cells, and CXCL13 were also necessary for development of interleukin 4 (IL-4)-producing type 2 helper T cells (T(H)2 cells), which suggests that T(H)2 differentiation can initiate outside the T cell zone.
语言:: eng
DOI:

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