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PMID: 2263471 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Synthesis and enzymatic polymerisation of 5-amino-1-(2'-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide-5'- triphosphate.

Nucleic acids research ·Vol. 18 ·No. 23 ·1990-12-11 ·Pages 7127-31

Pochet S, D'Ari R

Abstract

The chemical synthesis of 5-amino-1-(2'-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide, referred to as dZ, and of its 5'-triphosphate derivative (dZTP), from 2'-deoxyinosine is described. The polymerisation of dZTP using terminal deoxynucleotidyltransferase to give a homopolymer is also presented.

MeSH Terms
Aminoimidazole Carboxamide/analogs & derivatives,chemical synthesis,chemistry,metabolism Deoxyribonucleosides/chemical synthesis Deoxyribonucleotides/chemical synthesis,chemistry,metabolism Magnetic Resonance Spectroscopy Molecular Structure Polymers/chemistry,metabolism
Chemicals
Deoxyribonucleosides Deoxyribonucleotides Polymers 5-amino-1-(2'-deoxy-beta-ribofuranosyl)imidazole-4-carboxamide-5'-triphosphate Aminoimidazole Carboxamide 5-amino-1-(2'-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pochet S
Institut Pasteur, Unité de Chimie Organique, URA-CNRS 487, Paris, France.
D'Ari R
References (10)
10 references, click to expand
  1. Imidazole nucleosides and nucleotides.
    Chem Rev. 1967 Oct;67(5):533-63 PMID: 4863398
  2. Nucleosides of 2-azapurines and certain ring analogs.
    J Med Chem. 1972 Feb;15(2):182-7 PMID: 4536650
  3. 1-Glycosyl derivatives of 5-aminoimidazole-4-carboxamide.
    J Med Chem. 1972 Dec;15(12):1334-6 PMID: 4673837
  4. Factors affecting terminal deoxynucleotidyl transferase activity in cacodylate buffer.
    Biochem Biophys Res Commun. 1977 Oct 24;78(4):1219-26 PMID: 921773
  5. The enzymically catalysed transfer of the deoxyribosyl group from one purine or pyrimidine to another.
    Biochem J. 1952 Jan;50(3):384-97 PMID: 14915962
  6. Terminal transferase: use of the tailing of DNA and for in vitro mutagenesis.
    Methods Enzymol. 1983;100:96-116 PMID: 6312266
  7. Synthesis of carbocyclic purine nucleosides using key intermediates, carbocyclic AICA-ribosides.
    Nucleic Acids Symp Ser. 1987;(18):37-40 PMID: 3697147
  8. Synthesis of 2-deoxy-D-ribofuranosyl 5-amino- and 5-hydroxyaminoimidazole nucleosides by chemical methods and biotransformation.
    Nucleic Acids Symp Ser. 1989;(21):97-8 PMID: 2608495
  9. Ribosidation of 4-amino-imidazole-5-carboxamide by Escherichia coli.
    Nature. 1951 Dec 29;168(4287):1124 PMID: 14910663
  10. ZTP (5-amino 4-imidazole carboxamide riboside 5'-triphosphate): a proposed alarmone for 10-formyl-tetrahydrofolate deficiency.
    Cell. 1982 Jul;29(3):929-37 PMID: 6185232
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/18.23.7127
Published
1990-12-11
Pages
7127-31
Language
English
Region
England
NLM ID
0411011
PMCID
PMC332778
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/18.23.7127 PMC Full Text View journal details
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