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PMID: 22634346 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites.

Microbes and infection ·Vol. 14 ·No. 14 ·2012-11-00 ·Pages 1271-7

Coutinho-Silva R, Ojcius DM

Abstract

Extracellular nucleotides are danger signals involved in recognition and control of intracellular pathogens. They are an important component of the innate immune response against intracellular pathogens, inducing the recruitment of inflammatory cells, stimulating secretion of cytokines, and producing inflammatory mediators such as reactive oxygen species (ROS) and nitric oxide (NO). In the case of extracellular ATP, some of the immune responses are mediated through activation of the NLRP3 inflammasome and secretion of the cytokine, interleukin-1β (IL-1β), through a mechanism dependent on ligation of the P2X7 receptor. Here we review the role of extracellular nucleotides as sensors of intracellular bacteria and protozoan parasites, and discuss how these pathogens manipulate purinergic signaling to diminish the immune response against infection.

MeSH Terms
Adenosine Triphosphate/immunology Animals Bacteria/immunology Bacterial Infections/immunology Extracellular Space/immunology Host-Pathogen Interactions/immunology Humans Inflammasomes/immunology Inflammation/immunology Intracellular Space/immunology Models, Biological Parasites/immunology Parasitic Diseases/immunology
Chemicals
Inflammasomes Adenosine Triphosphate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Coutinho-Silva Robson
Biophysics Institute Carlos Chagas Filho, Federal University of Rio de Janeiro, RJ 21941-902, Brazil. rcsilva@biof.ufrj.br
Ojcius David M
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Article Info
Journal
Microbes and infection
Abbr.
Microbes Infect
ISSN
1769-714X
DOI
10.1016/j.micinf.2012.05.009
Email
rcsilva@biof.ufrj.br
Published
2012-11-00
Epub
2012-00-23
Pages
1271-7
Language
English
Region
France
NLM ID
100883508
PMCID
PMC4110109
Subset
IM
Grants
NIAID NIH HHS · R01 AI079004 · United States
NIDCR NIH HHS · R01 DE019444 · United States
External Links
PubMed source DOI: 10.1016/j.micinf.2012.05.009 PMC Full Text View journal details
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