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PMID: 22610083 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Mammalian iron metabolism and its control by iron regulatory proteins.

Biochimica et biophysica acta ·Vol. 1823 ·No. 9 ·2012-09-00 ·Pages 1468-83

Anderson CP, Shen M, Eisenstein RS, Leibold EA

Abstract

Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2). IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs encoding protein involved in iron uptake, storage, utilization and export. Over the past decade, significant progress has been made in understanding how IRPs are regulated by iron-dependent and iron-independent mechanisms and the pathological consequences of IRP2 deficiency in mice. The identification of novel IREs involved in diverse cellular pathways has revealed that the IRP-IRE network extends to processes other than iron homeostasis. A mechanistic understanding of IRP regulation will likely yield important insights into the basis of disorders of iron metabolism. This article is part of a Special Issue entitled: Cell Biology of Metals.

MeSH Terms
Animals Ferritins/genetics,metabolism Gene Expression Regulation Homeostasis/physiology Humans Ion Transport Iron/metabolism Iron Regulatory Protein 1/genetics,metabolism Iron Regulatory Protein 2/deficiency,genetics Mammals Mice Mice, Knockout Receptors, Transferrin/genetics,metabolism Response Elements/genetics Untranslated Regions/genetics
Chemicals
Receptors, Transferrin Untranslated Regions Ferritins Iron Iron Regulatory Protein 1 Iron Regulatory Protein 2
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Anderson Cole P
Department of Oncological Sciences, University of Utah, 15 N. 2030 E., Salt Lake City, UT 84112, USA.
Shen Macy
Eisenstein Richard S
Leibold Elizabeth A
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Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbamcr.2012.05.010
Published
2012-09-00
Epub
2012-00-17
Pages
1468-83
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC3675657
Subset
IM
Grants
NIGMS NIH HHS · R01 GM045201 · United States
NIDDK NIH HHS · DK068602 · United States
NIDDK NIH HHS · R01 DK068602 · United States
NIDDK NIH HHS · T32DK007115 · United States
NIDDK NIH HHS · R56 DK089212 · United States
NIGMS NIH HHS · GM45201 · United States
NIDDK NIH HHS · T32 DK007665 · United States
NIDDK NIH HHS · DK089212 · United States
NIDDK NIH HHS · R01 DK066600 · United States
NIDDK NIH HHS · T32DK007665 · United States
NIDDK NIH HHS · R56 DK066600 · United States
NIDDK NIH HHS · T32 DK007115 · United States
NIDDK NIH HHS · DK66600 · United States
External Links
PubMed source DOI: 10.1016/j.bbamcr.2012.05.010 PMC Full Text
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