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PMID: 22592980 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

The evolution of dynamin to regulate clathrin-mediated endocytosis: speculations on the evolutionarily late appearance of dynamin relative to clathrin-mediated endocytosis.

BioEssays : news and reviews in molecular, cellular and developmental biology ·Vol. 34 ·No. 8 ·2012-08-00 ·Pages 643-7

Liu YW, Su AI, Schmid SL

Abstract

Whereas clathrin-mediated endocytosis (CME) exists in all eukaryotic cells, we first detect classical dynamin in Ichthyosporid, a single-cell, metazoan precursor. Based on a key functional residue in its pleckstrin homology domain, we speculate that the evolution of metazoan dynamin coincided with the specialized need for regulated CME during neurotransmission.

MeSH Terms
Amino Acid Sequence Animals Blood Proteins/chemistry Clathrin/chemistry Dynamins/chemistry,classification Endocytosis Evolution, Molecular Humans Molecular Sequence Data Neurons/chemistry Organ Specificity Phosphoproteins/chemistry Phylogeny Protein Isoforms/chemistry Protein Structure, Tertiary Sequence Homology, Amino Acid
Chemicals
Blood Proteins Clathrin Phosphoproteins Protein Isoforms platelet protein P47 Dynamins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Liu Ya-Wen
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA.
Su Andrew I
Schmid Sandra L
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28 references, click to expand
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Article Info
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
Abbr.
Bioessays
ISSN
1521-1878
DOI
10.1002/bies.201200033
Published
2012-08-00
Epub
2012-00-16
Pages
643-7
Language
English
Region
United States
NLM ID
8510851
PMCID
PMC5715466
Subset
IM
Grants
NIMH NIH HHS · R37 MH061345 · United States
NIMH NIH HHS · MH61345 · United States
NIMH NIH HHS · R01 MH061345 · United States
NIGMS NIH HHS · GM42455 · United States
NIGMS NIH HHS · R01 GM042455 · United States
Corrections
CommentIn
PMID: 22744934
CommentIn
PMID: 25546812
External Links
PubMed source DOI: 10.1002/bies.201200033 PMC Full Text View journal details
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